Xencor (NASDAQ:XNCR – Get Free Report) and Cardiff Oncology (NASDAQ:CRDF – Get Free Report) are both small-cap healthcare companies, but which is the better investment? We will contrast the two companies based on the strength of their institutional ownership, dividends, earnings, risk, analyst recommendations, valuation and profitability.
Analyst Ratings
This is a summary of current ratings and target prices for Xencor and Cardiff Oncology, as reported by MarketBeat.com.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| Xencor | 1 | 3 | 6 | 1 | 2.64 |
| Cardiff Oncology | 1 | 3 | 3 | 0 | 2.29 |
Xencor presently has a consensus price target of $34.00, indicating a potential upside of 36.33%. Cardiff Oncology has a consensus price target of $7.50, indicating a potential upside of 705.15%. Given Cardiff Oncology’s higher probable upside, analysts clearly believe Cardiff Oncology is more favorable than Xencor.
Valuation & Earnings
This table compares Xencor and Cardiff Oncology”s gross revenue, earnings per share and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| Xencor | $125.58 million | 14.77 | -$91.92 million | ($2.17) | -11.49 |
| Cardiff Oncology | $590,000.00 | 122.82 | -$45.85 million | ($0.60) | -1.55 |
Cardiff Oncology has lower revenue, but higher earnings than Xencor. Xencor is trading at a lower price-to-earnings ratio than Cardiff Oncology, indicating that it is currently the more affordable of the two stocks.
Institutional and Insider Ownership
16.3% of Cardiff Oncology shares are held by institutional investors. 5.1% of Xencor shares are held by insiders. Comparatively, 8.8% of Cardiff Oncology shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.
Volatility and Risk
Xencor has a beta of 0.89, suggesting that its share price is 11% less volatile than the S&P 500. Comparatively, Cardiff Oncology has a beta of 1.42, suggesting that its share price is 42% more volatile than the S&P 500.
Profitability
This table compares Xencor and Cardiff Oncology’s net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| Xencor | -155.59% | -28.66% | -20.38% |
| Cardiff Oncology | -7,885.43% | -103.10% | -75.52% |
Summary
Cardiff Oncology beats Xencor on 8 of the 15 factors compared between the two stocks.
About Xencor
Xencor, Inc., a clinical stage biopharmaceutical company, focuses on the discovery and development of engineered monoclonal antibody and cytokine therapeutics to treat patients with cancer and autoimmune diseases. The company provides Sotrovimab that targets the SARS-CoV-2 virus; Ultomiris for the treatment of patients with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome; and Monjuvi for the treatment of patients with relapsed or refractory diffuse large B-cell lymphoma. It develops Plamotamab, a bispecific antibody, which is in Phase I clinical trial to treat non-Hodgkin lymphoma; Vudalimab, a bispecific antibody, which is in Phase II clinical trial to treat metastatic castration-resistant prostate cancer and other solid tumor types. The company is also developing XmAb306, which is in Phase I clinical trial to treat solid tumors; XmAb104, which is in Phase II clinical trial to treat patients with selected solid tumors; XmAb564 that is in Phase Ia clinical trial to treat autoimmune diseases; AMG 509, which is in Phase I clinical trial to treat prostate cancer; XmAb819 for patients with renal cell carcinoma; XmAb541 for the treatment of ovarian cancer; and XmAb662 which is in Phase I clinical trial to treat patients with solid tumors. In addition, the company develops VIR-3434, which is in Phase II clinical trial for patients with hepatitis B virus infection; and VIR-2482 that is in Phase 2 clinical trial to trat hepatitis B virus. The company develops AIMab7195 to reduce blood serum levels of IgE that mediates allergic responses and allergic disease; Obexelimab to treat autoimmune disease; and Xpro1595 to treat patients with Alzheimer's disease, and depression. It has a license agreement with Caris Life Sciences. Xencor, Inc. was incorporated in 1997 and is headquartered in Pasadena, California.
About Cardiff Oncology
Cardiff Oncology, Inc., a clinical-stage biotechnology company, develops novel therapies to treat various cancers in California. Its lead drug candidate is onvansertib, an oral selective Polo-like Kinase 1 Inhibitor to treatment a range of solid tumor cancers and KRAS/NRAS-mutated metastatic colorectal and metastatic pancreatic cancer, as well as investigator-initiated trials in triple negative breast cancer and small cell lung cancer; and TROV-054 is a Phase 1b/2 for FOLFIRI and bevacizumab. The company primarily serves pharmaceutical manufacturers. The company was formerly known as Trovagene, Inc. and changed its name to Cardiff Oncology, Inc. in May 2012. Cardiff Oncology, Inc. was incorporated in 1999 and is headquartered in San Diego, California.
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